The year 1659 in science and technology involved some significant events.

Astronomy Christiaan Huygens publishes Systema Saturnium, including the first illustration of the Orion Nebula.

Mathematics First known use of the term Abscissa, by Stefano degli Angeli.According to Moritz Cantor. Swiss mathematician Johann Rahn publishes Teutsche Algebra, containing the first printed use of the 'division sign' (÷, a repurposed obelus variant) as a mathematical symbol for division and of the 'therefore sign' (∴).

Medicine Thomas Willis publishes De Febribus.

Physics Christiaan Huygens derives the formula for centripedal force.

Births February 27 – William Sherard, English botanist (died 1728) June 3 – David Gregory, Scottish astronomer (died 1708)

Deaths October 10 – Abel Tasman, Dutch explorer (born 1603)

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