Route 385, or Highway 385, may refer to:
Canada New Brunswick Route 385 Quebec Route 385
Japan Japan National Route 385
United States Interstate 385 U.S. Route 385 Arkansas Highway 385 Florida State Road 385 Georgia State Route 385 Maryland Route 385 (former) New York State Route 385 New York State Route 385 (former) Ohio State Route 385 South Carolina Highway 385 Tennessee State Route 385 Texas: Texas State Highway Loop 385 Ranch to Market Road 385 Virginia State Route 385 Territories Puerto Rico Highway 385