EPN may refer to: End Polio Now, the polio eradication campaign of Rotary International and the World Health Organization Economic Prosperity Network, a global alliance initiative of the first Trump administration EPN (insecticide) Effective perceived noise, a measure of aircraft noise Electronic Payments Network, an electronic clearing house Enrique Peña Nieto, President of Mexico 2012–2018 Enterprise private network, an intranet in a large organisation Entomopathogenic nematode, thread worm that kills insects Epsin, a membrane protein Esplanade MRT station, Singapore (MRT station abbreviation) EUREF Permanent Network, a European GPS network National Polytechnic School (Ecuador) (Spanish: ), a university in Quito