Margulis is a surname that, like its variants, is derived from the Ashkenazi Hebrew pronunciation of the Hebrew word Margalit (, )), meaning 'pearl.' Notable people and characters with the name include:
Berl Broder (born Margulis; 1817–1868), Broder singer Dan Margulis (born 1951), author, expert on color correction and image retouching , Hero of the Soviet Union Evgeny Margulis (born 1955), Russian musician Grigory Margulis (born 1946), Russian mathematician, known for the Margulis lemma Lynn Margulis (1938–2011), American evolutionary biologist Margulis, a villain from the game series Xenosaga
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