Spafford may refer to:
People Belle S. Spafford (1895–1982), American president of the Relief Society David Spafford (born c. 1965), American university sports administrator Gene Spafford (born 1956), American professor of computer science at Purdue University Horatio Spafford (1828–1888), American religious leader and author of the hymn "It Is Well With My Soul" Michael Spafford (1935–2022), American artist Patricia Spafford Smith (1925–2002), American politician Ronnie Spafford (1928–2014), British army officer and philatelist Suzy Spafford (born 1945), American cartoonist, creator of "Suzy'z Zoo"
Places United States Spafford, Minnesota, an unincorporated community Spafford, New York, a town
Other uses Spafford (band), a band from Prescott, Arizona, United States