Andre Agassi defeated Todd Martin in the final, 6–4, 6–7(5–7), 6–7(2–7), 6–3, 6–2 to win the men's singles tennis title at the 1999 US Open. It was his second US Open title and fifth major title overall. With the win, Agassi returned to the world No. 1 singles ranking, ultimately ending Pete Sampras' record streak of six year-end No. 1 rankings, who withdrew due to a back injury just prior to the tournament.

Pat Rafter was the two-time defending champion, but lost to Cédric Pioline in the first round after succumbing to shoulder tendinitis.

This tournament marked the first main-draw major appearance of future world No. 1 and 2003 French Open champion Juan Carlos Ferrero; he lost to Greg Rusedski in the first round.

Seeds

Qualifying draw

Draw

Finals

Top half

Section 1

Section 2

Section 3

Section 4

Bottom half

Section 5

Section 6

Section 7

Section 8

References

External links Association of Tennis Professionals (ATP) – 1999 US Open Men's Singles draw 1999 US Open – Men's draws and results at the International Tennis Federation