William Hoffman may refer to:
William Hoffman (author) (1925–2009), American novelist William Hoffman (painter) (1924–1995), American painter William Hoffman (United States Army) (1807–1884), American military officer, led the Colorado River Expedition of 1858–1859 against the Mohave William Hofmann (1824–1902), American Union Army officer during the American Civil War Sonny Hoffman (William A. Hoffman, 1853–?), baseball player William F. Hoffmann (scientist), physicist at the University of Arizona who was awarded the status of Fellow from the American Physical Society William M. Hoffman (1939–2017), American playwright Bill Hoffman (American football) (1902–1994), American football player Bill Hoffman (bowling) (born 1971), ten-pin bowler Bill Hoffman (baseball) (1918–2004), American baseball player Billy Hoffman, American country music artist Bill Hoffman, one of the original developers of CMake and vice president of Kitware Bill Hoffman, candidate in the United States House of Representatives elections in Washington, 2010