C28 or C-28 may refer to:

Vehicles Cessna C-28, an American military transport aircraft , a C-class submarine of the Royal Navy Sikorsky C-28, an amphibious aircraft bought by the United States Army Air Corps

Other uses C28 road (Namibia) Caldwell 28, an open cluster Fighting Internet and Wireless Spam Act, an Act of the Parliament of Canada introduced as Bill C-28 C28 Music, an experimental electronic music artist