Senator Sykes may refer to:
Anthony Sykes (born 1972), Oklahoma State Senate Dinah Sykes (born 1977), Kansas State Senate James Sykes (Continental Congress) (1725–1792), Delaware State Senate James Sykes (governor) (1761–1822), Delaware State Senate Vernon Sykes (born 1951), Ohio State Senate
See also E. Walter Sikes (1868–1941), North Carolina State Senate