C52 or C-52 may refer to: C-52 (cipher machine) , an Admirable-class minesweeper of the Mexican Navy Caldwell 52, an elliptical galaxy Company C, 52d Infantry Regiment (Anti-Tank) of the United States Army Courage C52, a French racing car Douglas C-52, an American transport aircraft Evans Gambit, a chess opening , a Fiji-class light cruiser of the Royal Navy Ikarus C52, German ultralight aircraft JNR Class C52, a Japanese steam locomotive Vaginal cancer