Prine is a surname of either English or French (derived from Perrin) origin. Notable people with the surname include:
Andrew Prine (1936–2022), American actor Barney Prine (1841–1919), founder of the city of Prineville, Oregon which was originally named Prine Carl Prine (born 1966), American military investigative reporter John Prine (1946–2020), American singer-songwriter Linda Prine, American family physician and non-profit founder