A64 or A-64 may refer to:
Roads A64 road (England), a road connecting Leeds and Scarborough A64 motorway (France), a road connecting Toulouse and Bayonne A64 motorway (Germany), a road connecting the city of Luxembourg and Trier A64 highway (Spain), a road connecting the Autovía A-64 junction 367 km and Oviedo
Computing AMD64, a CPU architecture (further abbreviation A64) An Athlon 64 CPU A64 system on a chip designed by Allwinner Technology A64 (emulator), a Commodore 64 emulator for the Amiga Instruction set of AArch64
Other uses Benoni Defense, in the Encyclopaedia of Chess Openings (code "A64")