H2B could refer to:
A Honda powertrain modification consisting of a H series engine coupled to a B series drivetrain. H-2B visa, a US program for temporary/seasonal, non-agricultural employment by foreign nationals. Heavens to Betsy, a punk rock band from Olympia, Washington, USA. Histone H2B, one of 5 main histone proteins involved in the structure of chromatin in eukaryotic cells. H-IIB, a family of Japanese rockets. Help to Buy, financial assistance for purchasing a home in the UK.