Knob Creek can refer to:
Several streams in the US, including: Knob Creek, in Izard County, Arkansas Knob Creek, in Bullitt County, Kentucky Knob Creek, in Graves County, Kentucky Knob Creek (Miami Creek), a stream in Missouri Knob Creek (South Grand River), a stream in west central Missouri Knob Creek (Stouts Creek), a stream in Missouri Knob Creek, in Cleveland County, North Carolina Knob Creek, in Lauderdale County, Tennessee Knob Creek, in Lawrence County, Tennessee Knob Creek, in Sevier County, Tennessee Knob Creek, in Washington County, Tennessee
Other Knob Creek Farm, boyhood home of Abraham Lincoln, in LaRue County, US Knob Creek (bourbon), a brand of bourbon whiskey made by Beam Suntory