PME may refer to:
Electronics and computing
Physical Medium Entity, an abstract defined by the IEEE 802.3 standard Power Management Event, both a signal sent by a PCI bus and in Wake-on-LAN standard. Protective Multiple Earthing, another name for the TN−C−S earthing system Particle mesh Ewald, an algorithm used in calculating electrostatic forces in molecular dynamics simulations in computational biology and physics
Education Professional Military Education, a term for systems for educating military personnel in the United States Professional Master of Education, a type of initial teacher education qualification in Ireland.
Other Progressive myoclonus epilepsies, a group of neurodegenerative diseases characterized by myoclonus (erratic muscle twitching) Public Market Equivalent, a measure of historical performance of private equity Pi Mu Epsilon, a U.S. national mathematics honor-society Pacific Mozart Ensemble, the old name of Pacific Edge Voices, a choir in California P.M.E., a clerical abbreviation for the members of the Roman Catholic Société des Missions-Étrangères du Québec