CWD may refer to:
Biology Cantabrian Water Dog, Spanish dog breed Cell wall-deficient bacteria (or L forms) Chronic wasting disease, of deer Coarse woody debris, fallen trees and branches Coffee wilt disease, in coffee trees Common and well-documented, of human leukocyte antigen alleles
Train stations Chatswood railway station, Sydney, Australia Chawinda railway station, Punjab province, Pakistan Collingwood railway station, Melbourne, Australia Creswell railway station, Derbyshire, England
Technology Cadwaladerite, an aluminium halide mineral A locomotive; see Indian locomotive class XD Current working directory, in computing
Other uses Canada's Worst Driver, a television series (2005–2018) Clwyd, a preserved county of Wales (in genealogy) Woods Cree language, spoken in Canada (ISO 639-3:cwd)