VPI may refer to:

Science and technology Vapor phase infiltration, a technique Velopharyngeal insufficiency, a medical disorder Verilog Procedural Interface, a programming interface Virtual path identifier, in computer networking Virtual protocol interconnect, a feature of Mellanox Technologies

Organizations Vertical Politics Institute, a conservative political action committee Vietnam Petroleum Institute Virginia Polytechnic Institute and State University, official name of Virginia Tech, a US university Visegrad Patent Institute, a patent organization created by the four Visegrad countries VPI Industries, a manufacturer of phonographs

Other uses Vocational Preference Inventory, by John L. Holland