The 1942 Tampa Spartans football team represented the University of Tampa as an independent during the 1942 college football season. Led by Melvin Vines in his first season as head coach, the Spartans compiled an overall record of 5–5. The team played home games at Phillips Field in Tampa, Florida.
Tampa was ranked at No. 264 (out of 590 college and military teams) in the final rankings under the Litkenhous Difference by Score System for 1942.
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