Dreyfuss is a surname of German origin. Notable people with this surname include:
Barney Dreyfuss (1865–1932), baseball entrepreneur, co-founder of the World Series Gideon Dreyfuss, molecular biologist, Howard Hughes Medical Institute and University of Pennsylvania Henry Dreyfuss (1904–1972), industrial designer Joel Dreyfuss (born 1945), editor-in-chief of Red Herring Laura Dreyfuss (born 1988), American actress Richard Dreyfuss (born 1947), American actor Robert Dreyfuss, American freelance investigative journalist Rochelle C. Dreyfuss, American law professor
See also Dreyfus (disambiguation), Dreyfus (surname) Dreifuss Orvil Dryfoos (1912–1963), publisher of The New York Times from 1961 to 1963