2C-Se-TFM is a designer drug from the substituted phenethylamine family, which produces psychedelic-like effects in animals such as a head twitch response. It was first synthesised by Josh Hartsel and colleagues in 2024. It has a binding affinity (Ki) of 3.2 nM at the serotonin receptor 5-HT2A and an EC50 of 3.6 nM, acting as a full agonist. Aside from 2C-Se, it is the only psychedelic drug containing a selenium atom, as while other related analogues such as the ethyl compound 2C-Se-2 and the propyl derivative 2C-Se-7 have been proposed as theoretical compounds, neither is known to have been synthesised. It is a controlled substance in Canada under phenethylamine blanket-ban language.
See also 2C (psychedelics) 2C-TFE 2C-T-4 2C-T-21 2C-T-TFM 2C-Te
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