De la Bárcena is a Spanish surname. Notable people with the surname include:
Guillermo Cañedo de la Bárcena (1920–1997), Mexican entrepreneur and football manager José Patricio de la Bárcena (1807–1881), Mexican politician Mariano de la Bárcena (1842–1899), Mexican engineer, botanist, and politician Pedro de la Bárcena (1768–1836), Spanish military
See also Bárcena (surname)