Panhandle Railroad or Panhandle Railway may refer to: Pittsburgh, Cincinnati, Chicago and St. Louis Railroad across the Northern Panhandle of West Virginia Pan Handle Railway (1861–1868), a predecessor of the above in Pennsylvania and West Virginia Pan Handle Railroad (1868–1871), a predecessor of Pennsylvania Railroad subsidiary Pittsburgh, Wheeling and Kentucky Railroad in West Virginia Panhandle Railway (1887–1898), a predecessor of Atchison, Topeka and Santa Fe Railway subsidiary Panhandle and Santa Fe Railway in Texas Panhandle and Santa Fe Railway
See also Panhandle Trail