EZS-8, also known as 3-(2-aminoethyl)quinazoline-2,4-dione, is a very-low-potency serotonin 5-HT2A receptor partial agonist related to ketanserin. It has about 0.15% of the potency ( = 66,000nM) and 46% of the efficacy () of serotonin as a serotonin 5-HT2A receptor agonist in vitro. The N-(2-methoxy)benzyl analogue of EZS-8, RH-34, has 250-fold greater potency as a serotonin 5-HT2A receptor agonist in comparison. EZS-8 was first described in the scientific literature by 1999. N-Benzyl derivatives of EZS-8 like RH-34 had been described as early as 1996 or 1998. Some other analogues of EZS-8 such as WL299 and WL163 have been described as well.
See also List of miscellaneous 5-HT2A receptor agonists
References
External links EZS-8 - Isomer Design