2-Phenylmorpholine (code name PAL-632) is the parent compound of the substituted phenylmorpholine class of compounds. Examples of 2-phenylmorpholine derivatives (i.e., substituted phenylmorpholines) include phenmetrazine (3-methyl-2-phenylmorpholine), phendimetrazine ((2S,3S)-3,4-dimethyl-2-phenylmorpholine), and pseudophenmetrazine ((2RS,3SR)-3-methyl-2-phenylmorpholine), which are monoamine releasing agents (MRAs) and psychostimulants. 2-Phenylmorpholine itself is a potent norepinephrine–dopamine releasing agent (NDRA) and hence may act as a stimulant similarly.
+ Compound Ref Phenethylamine 10.9 39.5 >10,000 Dextroamphetamine 6.6–10.2 5.8–24.8 698–1,765 Dextromethamphetamine 12.3–14.3 8.5–40.4 736–1,292 2-Phenylmorpholine 79 86 20,260 Phenmetrazine 29–50.4 70–131 7,765–>10,000 Phendimetrazine >10,000 >10,000 >100,000 Pseudophenmetrazine 514 >10,000 () >10,000 Notes: The smaller the value, the more strongly the drug releases the neurotransmitter. The assays were done in rat brain synaptosomes and human potencies may be different. See also Monoamine releasing agent § Activity profiles for a larger table with more compounds. Refs:
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