Leathem is a surname. Notable people with the name include:
Andy Leathem (born 1977), English professional rugby league footballer Bob Leathem (1925–1996), Canadian football player Janet Leathem, New Zealand psychology academic specializing in traumatic brain injury John Leathem, murderer
See also Leathem D. Smith Shipbuilding Co., shipyard and dry dock company in Sturgeon Bay, Door County, Wisconsin, US Quinn v Leathem, important case historically for British labour law