The 1981 Delaware State Hornets football team represented Delaware State College (now known as Delaware State University) as a member of the Mid-Eastern Athletic Conference (MEAC) during the 1981 NCAA Division I-AA football season. Led by first-year head coach Joe Purzycki, the Hornets compiled an overall record of 2–9, with a mark of 1–4 in conference play, and finished fifth in the MEAC.

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