Jayasena (Sinhalese: ජයසේන) is predominantly a Sinhalese family name and rarely a given name (from Sri Lanka). Notable people with the name include:
Jayasena (Jain monk) (), Indian monk Jayasena (), Siamese king Jayasena Dissanayake ()), Sri Lankan politician Hemantha Jayasena (born 1971), Sri Lankan-born Italian cricketer Henry Jayasena (1931–2009), Sri Lankan actor J. P. Jayasena (1921–1990), Ceylonese politician L. B. Jayasena (1920–?), Sri Lankan politician Ranmith Jayasena (born 2000), Sri Lankan cricketer Sumedha Jayasena (born 1952), Sri Lankan politician