Jayathilake is a Sinhalese family name from Sri Lanka. In Sinhalese it is "ජයතිලක". Other ways to write this surname in romanized letters are "Jayatilleka" and "Jayatilake" Notable people with the surname include:
Amaranath Jayathilake (1937–2013), Sri Lankan journalist Chathuranga Jayathilake (born 1991), Sri Lankan cricketer C. L. V. Jayathilake, Sri Lankan engineer Malith Jayathilake, Sri Lankan politician Ransilu Jayathilake (born 1987), Sri Lankan powerlifter Supeshala Jayathilake (born 1995), Sri Lankan cricketer