Ganzel is a surname. Notable people with the name include:
Babe Ganzel (1901–1978), American baseball player Charlie Ganzel (1862–1914), American baseball player John Ganzel (1874–1959), American baseball player and manager Liesel Schuch-Ganzel (1891–1990), German coloratura soprano Teresa Ganzel, American actor and comedian Toni M. Ganzel, American otolaryngologist and academic administrator