Massei is an Italian surname. Notable persons with that surname include:

Joe Massei (1899 – 1971), American gangster of Italian-Irish origins Girolamo Massei (c. 1530 – c. 1614), Italian Mannerist painter active mostly in Rome Oscar Massei (born 1934), Argentine retired professional football

See also Masei Massi (disambiguation) Mazzei, surname Villa Massei, hunting lodge and garden in Tuscany