Niphargellus is a genus of Amphipod crustaceans within the family Niphargidae. The genus contains three known species, which are characterized by the absence of D-setae on the Amphipods mandibular palp. The presence or absence of setae, specifically the D-setae, is a distinguishing feature used to classify organisms within the genus.

Niphargellus species live in freshwater environments such as caves, springs and the interstitial spaces of river beds.Grabner, Daniel & Weber, Dieter & Weigand, Alexander. (2020). Updates to the sporadic knowledge on microsporidian infections in groundwater amphipods (Crustacea, Amphipoda, Niphargidae). Subterranean Biology. 33. 71-85. 10.3897/subtbiol.33.48633. Species are native to Europe, where they can be found in England, Germany and the Czech Republic.

A cladogram according to the Catalogue of Life:

Species list Niphargellus arndti (Schellenberg, 1933) - Found living in freshwater springs in the Czech Republic. Niphargellus glenniei (Spooner, 1952) - Found living in cave water in Southwest England. Niphargellus nolli (Schellenberg, 1938) - Found living in interstitial spaces within riverbeds in Germany.

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