UPI most commonly refers to: United Press International, a global news agency headquartered in Miami, Florida Unified Payments Interface, an Indian instant payment system

UPI may also refer to:

Organizations Universal Pictures International, an American film studio Union of Italian Provinces () Ural Polytechnic Institute, now Ural State Technical University, Russia Indonesia University of Education () Finnish Institute of International Affairs ()

Computing Intel Ultra Path Interconnect, a processor interconnect

Financial services UnionPay, a Chinese payment cards company Unified Payments Interface, of National Payments Corporation of India

Places Upi, Maguindanao del Norte, Philippines (also known as North Upi) South Upi, Maguindanao del Sur, Philippines Upi, an ancient indigenous settlement in Northwest Field (Guam) Upi or Upu, historic region surrounding Damascus

Other uses Upi Darmayana Tamin (born 1970), Indonesian chess player Urpo Pikkupeura (born 1957), former Finnish skater Ulcer Performance Index, stock market risk measure