Pagonis is a surname and given name. Notable people with the name include:
surname Anastasia Pagonis (born 2004), American Paralympic swimmer Kostas Pagonis (born 1985), Greek footballer Nenad Pagonis (born 1987), Serbian kickboxer Pidgeon Pagonis (born 1986), American intersex activist William Pagonis (born 1941), American Army general
given name Pagonis Vakalopoulos (born 1965), Greek footballer