The 2021–22 Coupe de France preliminary rounds, Brittany was the qualifying competition to decide which teams from the leagues of the Brittany region of France took part in the main competition from the seventh round.
A total of fourteen teams qualified from the Brittany preliminary rounds. In 2020–21, US Montagnarde progressed furthest in the main competition, reaching the round of 32 before losing to Olympique Saumur FC.
Draws and fixtures On 28 June 2021, the Brittany league announced that 701 teams had entered the competition. The first round draw was published on 29 July 2021, with 578 teams entering at that stage. The second round draw was published on 31 August 2021, with 105 teams from Régionale 2 and Régionale 1 entering at this stage. The third round draw was published on 9 September 2021, with the teams from Championnat National 3 entering at this stage. The fourth round draw was published on 23 September 2021, with the teams from Championnat National 2 entering at this stage. The fifth round draw, featuring the teams from Championnat National, was made on 6 October 2021. The sixth round draw was published on 20 October 2021.
First round These matches were played on 29 August 2021, with one postponed until 5 September 2021.