Xandão is a hypocorism of the name Alexandre, and means "Big Alexander" or "Alexander Sr." in Portuguese. Xandão may refer to:
Alexandre de Moraes, Brazilian jurist and a judge at the Brazilian Supreme Federal Court Xandão (footballer, born 1988), Brazilian football defender Alexandre Luiz Reame Xandão (footballer, born 1990), Brazilian football defender Alexandre Rodrigues Soares Xandão Menezes, Brazilian guitarist