Palmer Creek is a stream in Chariton County in the U.S. state of Missouri. It is a tributary of the Missouri River.

The stream headwaters arise at and it flows generally south passing the community of Indian Grove.Indian Grove, MO, 7.5 Minute Topographic Quadrangle, USGS, 1948 (1979 rev.) It continues to the south entering the Missouri River floodplain passing under US Route 24 approximately midway between Brunswick and Keytesville. The stream passes through the Cut-Off Lake and enters the Missouri just west of the Chariton River confluenceCambridge, MO, 7.5 Minute Topographic Quadrangle, USGS, 1956 (1979 rev.) at .

Palmer Creek was named after Maillard Palmer, the first state representative from Chariton County.

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