Pierantonio is a given name of Italian origin. Notable people with this name include:
Pierantonio Clementi (born 1947), Italian biathlete Pierantonio Costa (1939–2021), Italian businessman and diplomat Pierantonio Stiattesi (), Italian Renaissance artist Pierantonio Tasca (1858–1934), Italian opera composer Pierantonio Tremolada (born 1956), Italian catholic bishop
See also A.S.D. Pierantonio Calcio 1965, an Italian association football club