Spitzmüller is a German surname. Notable people with the surname include:
Alexander Spitzmüller (1862–1953), Austrian lawyer, bank director, and politician Anna Spitzmüller (1903–2001), Austrian art historian, curator, and educator István Spitzmüller (born 1986), Hungarian footballer
See also Pamela Spitzmueller (1950–2025), American conservator and book artist