Muhammad Rafique may refer to:
Muhammad Rafique (politician, born 1941), Pakistani politician who was a Member of the Provincial Assembly of the Punjab Muhammad Rafique (politician, born 1960), Pakistani politician who was a Member of the Provincial Assembly of Sindh Muhammad Rafique (mathematician) (1940-1996), Pakistani mathematician
See also Mohammad Rafiq (disambiguation) Mohammed Rafi (1924–1980), Indian singer Mohammed Rafi (footballer) (born 1982), Indian footballer Mohammad Rafi (cricketer) (born 1998), Indian cricketer Mohammed Rafi Sauda (1713–1781), Indian Urdu poet