Senator Henderson may refer to:
Members of the Australian Senate George Henderson (Australian politician) (1857–1933), Australian Senator from Western Australia from 1904 to 1923 Sarah Henderson (born 1964), Australian Senator from Victoria since 2019
Members of the United States Senate Charles Henderson (Nevada politician) (1873–1954), U.S. Senator from Nevada from 1918 to 1921 James Pinckney Henderson (1808–1858), U.S. Senator from Texas from 1857 to 1858 John B. Henderson (1826–1913), U.S. Senator from Missouri from 1862 to 1869 John Henderson (Mississippi politician) (1797–1857), U.S. Senator from Mississippi from 1839 to 1845
United States state senate members Deidre Henderson (born 1974), Utah State Senate Frank Henderson (South Dakota politician) (1928–2012), South Dakota State Senate James Henderson Jr. (1942–2022), Arizona State Senate John M. Henderson (1868–1947), Texas State Senate John S. Henderson (1846–1916), North Carolina State Senate Mike Henderson (politician) (born 1958/59), Missouri State Senate Monroe Henderson (1818–1899), New York State Senate Richard Henderson (Hawaii politician) (1928–2026), Hawaii State Senate Thomas Henderson (New Jersey politician) (1743–1824), New Jersey State Senate Thomas J. Henderson (politician) (1824–1911), Illinois State Senate Warren Henderson (1927–2011), Florida State Senate