Mary Griffith may refer to:
Mary Pix (née Griffith; 1666–1709), English novelist and playwright Mary Griffith (writer) (1772–1846), American writer, horticulturist, and scientist Mary Harriett Griffith (1849–1930), Australian philanthropist Mary Agnes Christina Mesmer Griffith (1864–1948), called Tina, oldest daughter of Louis and Catherine Mesmer Mary Emma Griffith Marshall (née Griffith; 1888–1925), American editor and librarian Mary Lavinia Griffith (1906–1993), American rancher and conservationist Mary Griffith (activist) (1934–2020), American LGBT rights activist
See also Mari Griffith (1940–2019), Welsh broadcaster, singer, and author