Kruis (; "Cross") is a surname of primarily Dutch and Flemish origin. Notable people with the surname include:
Andrea Kruis (born 1962), Dutch comics artist Deon Kruis (born 1974), South African cricketer George Kruis (born 1990), British rugby union player Jan Kruis (1933–2017), Dutch comics artist Konrad Kruis (1930–2022), German lawyer and judge Sebastian Kruis (born 1989), Dutch politician
See also Gert Kruys (born 1961), Dutch football player and manager Rick Kruys (born 1985), Dutch football player and manager, son of Gert Kruys, Dutch patrician family Zilveren Kruis, Dutch health insurance company