DeGrazia or De Grazia is a surname. Notable people with the surname include:
Alfred de Grazia (1919–2014), American political scientist and author (born 1959), Venezuelan politician and National Assembly deputy David DeGrazia (born 1962), American moral philosopher Domingo DeGrazia, American politician Don De Grazia, professor Edward de Grazia (1927–2013), American lawyer, writer and activist Ettore DeGrazia (1909–1982), American painter, sculptor, composer, actor, director, designer, architect, jeweler, and lithographer Jazmín De Grazia (1984–2012), Argentine model and television presenter Lorenzo De Grazia (born 1995), Italian footballer Margreta de Grazia (born 1946), Shakespeare scholar Sebastian de Grazia (1917–2000), American author Victor deGrazia (1929–2005), American politician Victoria de Grazia, American professor and historian