Pagano is an Italian surname. Notable people with the name include:
A. J. Pagano (), American college football player Bartolomeo Pagano (1878–1947), Italian motion picture actor Biagio Pagano (born 1983), Italian footballer Cesare Pagano (born 1969), Italian Camorrista (mobster) Chuck Pagano (born 1960), American football coach Chuck Pagano (ESPN), American business executive Daniel Pagano (born 1953), American mobster Darlene Pagano, American lesbian feminist activist Ernest Pagano (1901–1953), American screenwriter Francesco Mario Pagano (1748–1799), Italian author and jurist Giuseppe Pagano (1896–1945), Italian architect John Pagano (born 1967), American football coach Linda Pagano (1957–1974/75), American murder victim Lindsay Pagano (born 1986), American singer Luca Pagano (born 1978), Italian poker player Lucas Rodriguez Pagano (born 1980), Argentine footballer Michele Pagano (painter) (1697–1732), Italian painter Michele Pagano (biochemist), biochemist and cancer biologist Nazario Pagano (born 1957), Italian politician Sarah Pagano (born 1991), American long distance runner Silvio Pagano (born 1985), Italian-German footballer Ugo Pagano (born 1951), Italian economist and professor