Speziale may refer to:
People Charles Speziale (1948 – 1999), American Aerospace engineer Jerry Speziale (born c. 1959), American law enforcement officer John A. Speziale (1922–2005), justice of the Connecticut Supreme Court Marie Speziale (born c. 1945), American musician
Artistic works Lo speziale, an opera buffa by Joseph Haydn
Places Speziale, a village in Italy