Gilzean is a surname from Scotland. Notable people with the surname include:
Footballers Alan Gilzean (1938–2018), mostly played for Dundee, Tottenham Ian Gilzean (born 1969), played for various clubs
Politicians Andrew Gilzean (1877–1957), Labour Party politician Hugh Reid (politician) (1836–1911), Scottish journalist and politician
Other Butch Gilzean, a character in the television series Gotham