DeButts, sometimes spelt as deButts or De Butts, is a surname. Notable people with the surname include:

Augustus De Butts (1770–1853), British Royal Engineer officer Elisha De Butts (1773–1831), American physician John D. deButts (1915–1986), American businessman Harry A. deButts (d. 1983), American businessman Henry De Butts, United States Army captain Samuel DeButts, American physician Freddie De Butts, British Brigadier and diplomat