Barzilai is a Hebrew surname. Notable people with the surname include:
Gad Barzilai (born 1958), Israeli professor of law, political science and international studies Judah ben Barzilai, 12th century Catalan Talmudist Netta Barzilai (born 1993), Israeli singer, recording artist and looping artist Nir Barzilai (born 1955), founding director of the Institute for Aging Research Salvatore Barzilai (1860–1939), Italian journalist and politician Shmuel Barzilai (born 1957), Israeli cantor Yisrael Barzilai (1913−1970), Israeli politician and government minister
See also Barzilai Medical Center, a 617-bed hospital in Ashkelon, southern Israel Joseph Berger-Barzilai (1904–1978), founding member and secretary of the Communist Party of Palestine Barzillai, mentioned in the Old Testament Barzali Barzilay
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