Arguello () is a Spanish surname. Notable people with the surname include:
Casimiro Abdon Irala Arguello (1936–2024), known as Padre Irala, Paraguayan-Brazilian Jesuit priest, writer, musician and songwriter Christine Arguello (born 1955), American lawyer, jurist and judge Irma Arguello, Argentine international security expert Marcella Arguello (born 1985), American comedian Ricardo Arguello (fl. 1932), Mexican sprinter