Guion is a given name and surname.
Notable people Given name Guion Bluford (born 1942), American aerospace engineer Guion Griffis Johnson (1900–1989), American historian
Surname Connie Guion (1882–1971), American physician and educator David Guion (born 1967), French football coach David W. Guion (1892–1981), American composer Isaac Guion (1755–1823), American military officer and settler John Isaac Guion (1802–1855), American politician from Mississippi Letroy Guion (born 1987), American football player Renée Guion (born 1999), American soccer player Stephen Barker Guion (1820–1885), American businessman, co-founder of the Williams & Guion Black Star Line Walter Guion (1849–1927), American politician from Louisiana William Howe Guion (1817–1890), American businessman, co-founder of the Williams & Guion Black Star Line
See also Guyon, a variant spelling